This London matchup has the potential to be one of the more unpredictable games of early October. The Bills enter as a significant favorite, around Bills -5.5 at -110, while Jacksonville sits at +5.5. The total ranges from 47 to 48 depending on the book.
Buffalo’s offense has found rhythm after a slow Week 1 performance. They’ve been one of the most efficient passing offenses in football, ranking top five in yards per attempt and red-zone conversion rate. When they’re clicking, they remain one of the toughest covers in football because of their vertical threats and quarterback mobility.
Jacksonville, meanwhile, has been frustratingly inconsistent. They move the ball well between the 20s but have had issues punching it in. Bettors have noticed the Jaguars settling for field goals far too often. Against Buffalo, that’s a problem. Field goals don’t beat the Bills; touchdowns do.
For bettors, this raises questions about whether Jacksonville can keep pace. The Bills have dominated teams with average pass rushes, and Jacksonville’s pass rush has struggled to generate pressure with four. Without pressure, Buffalo can dictate tempo.
On the other hand, Buffalo’s defense has shown occasional vulnerability to the run. Jacksonville has the personnel to exploit that with their inside-out rushing attack. If they can control the clock, they can shorten the game and cover the spread.
Travel also plays a role. Jacksonville is already in London and acclimated. Buffalo is arriving later, which historically can matter in the first half.
First-half Jacksonville props may hold value due to that travel edge.
Still, Buffalo’s ceiling makes them dangerous. If they get hot early, this game could get away from Jacksonville quickly.
Prediction: Bills -5.5
